HCID 66891987, compound → HCID 66894201, compound

Participants

Reaction Steps

1-(5-Nitro-1-benzofuran-7-yl)piperidine (630 mg, 2.56 mmol; Intermediate 4) was dissolved in EtOAc (50 mL), PtO2 added and the mixture stirred under H2 for 36 h. Filtration through Celite and concentration of the filtrate furnished 7-piperidin-1-yl-1-benzofuran-5-amine. Yield: 540 mg (98%). 1H NMR (400 MHz, CDCl3) δ ppm 1.59-1.65 (m, 2H), 1.71-1.83 (m, 4H), 3.21-3.26 (m, 4H), 3.55 (br s, 2H), 6.19 (d, 1H), 6.45 (d, 1H), 6.56 (d, 1H), 7.51 (d, 1H); GC-MS (EI+) for C13H16N2O m/z 216 M+.

Provenance & Evidence