Hydrazine hydrate (1:1) → HCID 21864857, compound

Participants

Reaction Steps

tert-Butyl 4-(5-nitro-1-benzofuran-7-yl)piperazine-1-carboxylate* (1 g, 2.9 mmol) was dissolved in THF/EtOH (1:4). An excess of Raney-Ni (slurry in ethanol) was added followed by hydrazine-hydrate (0.58 g, 11.5 mmol). The reaction mixture was stirred at room temperature overnight. Filtration and evaporation afforded 1.19 g of the title product that was used in the next step without further purification. HPLC purity 93%, RT=1.71 min (System A; 10-97% MeCN over 3 min). *Previously described in WO 2002100822.

Provenance & Evidence