Sodium Carbonate → HCID 66893448, compound

Participants

Reaction Conditions

Reaction Steps

Pd(PPh3)4 (240 mg, 209 mmol) was added to 7-iodo-5-nitro-1-benzofurane (1.00 g, 3.45 mmol) in DME (11 mL) and the resulting mixture was stirred for 10 min. The color went from dark red to mustard yellow. Pyrimidine-5-boronic acid (0.24 g, 0.21 mmol) and 1 M Na2CO3 (5 mL) were added and the reaction mixture was refluxed at 100° C. for 2.5 h. The mixture was concentrated in vacuo and the residue was dissolved in 1 M HCl (50 mL) and washed with diethyl ether (50 mL). The aqueous layer was made basic (pH 8), by addition of K2CO3, and extracted with chloroform (3×). The combined organic layers were dried with K2CO3, filtered and concentrated to afford 0.455 g (55%) of a yellow solid. HPLC 100%, RT: 1.870 min (System A; 10-97% over 3 min). 1H NMR (270 MHz, CDCl3) δ ppm 7.06 (d, J=2.47 Hz, 1H) 7.90 (d, J=2.23 Hz, 1H) 8.45 (d, J=2.23 Hz, 1H) 8.63 (d, J=2.23 Hz, 1H) 9.28-9.31 (m, 3H). LC-MS 242 (M+H)+.

Provenance & Evidence