2-Chlorobenzenesulfonyl chloride → HCID 66894092, compound

Participants

Reaction Steps

2-[4-(5-Amino-1-benzofuran-7-yl)piperazin-1-yl]-N,N-diethylacetamide (0.095 g, 0.29 mmol; Intermediate 23) was reacted with 2-chlorobenzenesulfonyl chloride according to the procedure of Intermediate 19. Yield: 0.06 g (41%) after purification by preparative HPLC (System E; 20-50% MeCN). 1H NMR (400 MHz, DMSO-d6) δ ppm 1.08 (t, J=6.9 Hz, 3H) 1.15 (t, J=6.9 Hz, 3H) 3.09-3.43 (m, 7H) 3.55-3.65 (m, 2H) 3.67-3.76 (m, 2H) 4.39 (s, 2H) 6.62 (d, J=1.0 Hz, 1H) 6.86 (d, J=1.3 Hz, 1H) 6.93 (d, J=1.5 Hz, 1H) 7.47 (t, J=7.0 Hz, 1H) 7.60 (q, J=7.7 Hz, 2H) 7.91 (d, J=1.3 Hz, 1H) 8.01 (d, J=7.8 Hz, 1H) 10.08 (s, 1H) 10.46 (s, 1H). HPLC purity 92%, RT=1.85 min (System A; 10-97% MeCN over 3 min). MS (ESI+) m/z 505.2 (M+H)+.

Provenance & Evidence