Ammonia → HCID 66893029, compound

Participants

Reaction Conditions

Reaction Steps

3-(7-Bromo-1-benzofuran-2-yl)-1-azabicyclo[2.2.2]oct-2-ene (300 mg, 0.986 mmol; Intermediate 25) was dissolved in methanol (2 mL). A solution of concentrated aqueous ammonia (25%; 10 mL) and CuCl2 (15 mg) were added and the resulting mixture was heated at 120° C. for 48 h. The mixture was run through a silica plug using methanol/ammonia solution (9:1) as eluent. Concentration in vacuo furnished 236 mg of the crude title product. This material was used directly in subsequent experiments.

Provenance & Evidence