HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1161998Generated: October 28, 2026
1,10-Phenanthroline → HCID 66893251, compound
https://huagongshe.com/reaction/1161998
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 1,10-Phenanthroline | HCID 1318 | — |
| Reactant | (+-)-3-Quinuclidinol | HCID 15381 | — |
| Reactant | HCID 21864764 | HCID 21864764 | — |
| Catalyst | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | HCID 66893251 | HCID 66893251 | 100% |
Reaction Steps
7-Iodo-5-nitro-1-benzofuran (1.00 g, 3.46 mmol), quinuclidin-3-ol (1.10 g, 8.65 mmol), 1,10-phenanthroline (0.25 g, 1.38 mmol), CuI (0.13 g, 0.69 mmol) and toluene (20 mL) were mixed together and heated at 140° C. overnight. The solvent was removed in vacuo and the crude product was purified by flash chromatography (eluent: hexane and chloroform:MeOH:triethylamine; 9:0.9:0.1) to give 3-[(5-nitro-1-benzofuran-7-yl)oxy]quinuclidine (3.46 mmol).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07820675B2 |
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| Source dataset | uspto-grants-2010_10 |
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| ORD ID | ord-d4f1009bba4749489248532117fc2175 |
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| Source note | uspto-grants-2010_10 |
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