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Pyridine → HCID 66891955、化合物
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Pyridine | HCID 1049 | — |
| 反応物 | 6-Methoxy-m-toluenesulfonyl chloride | HCID 145149 | — |
| 反応物 | 7-Bromo-2-trimethylsilanyl-benzofuran-5-ylamine | HCID 59520013 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | HCID 66891955 | HCID 66891955 | 100% |
反応手順
Coupling of the amine (4.5 g, 15.9 mmol) from Step 1 with 2-methoxy-5-methylphenylsulfonyl chloride (3.5 g, 15.9 mmol) in dichloromethane (200 mL) using pyridine as a base (3.2 mL, 40 mmol) required 2.5 hours at ambient temperature. Washing the resulting mixture with water, drying and concentration yielded 7.4 g (100%) of N-(7-bromo-2-trimethylsilanyl-benzofuran-5-yl)-2-methoxy-5-methyl-benzenesulfonamide as a dark orange solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07820675B2 |
| 出典データセット | uspto-grants-2010_10 |
| ORD ID | ord-cbdc6dea8ad4483987320034baa35609 |
| 出典メモ | uspto-grants-2010_10 |