(2R)-1-Ethyl-2-pyrrolidinemethanamine → {[(2R)-1-Ethylpyrrolidin-2-yl]methyl}(5-nitro-1-benzofuran-7-yl)amine

HRID 1162013Notes

Reaction equation

HRID 1162013 reaction equation
[N:1]1([CH2:7][CH2:8][NH:9][C:10]2[C:18]3[O:17][CH:16]=[CH:15][C:14]=3[CH:13]=[C:12]([N+:19]([O-:21])=[O:20])[CH:11]=2)[CH2:6][CH2:5]O[CH2:3][CH2:2]1.N[CH2:23][C@H]1CCCN1CC>>[CH2:2]([N:1]1[CH2:6][CH2:5][CH2:23][C@@H:7]1[CH2:8][NH:9][C:10]1[C:18]2[O:17][CH:16]=[CH:15][C:14]=2[CH:13]=[C:12]([N+:19]([O-:21])=[O:20])[CH:11]=1)[CH3:3]

Participants

3

Reactant 2

HCID 854138(2R)-1-Ethyl-2-pyrrolidinemethanamineHCID 66893941HCID 66893941, compound

Product 1

HCID 66893445{[(2R)-1-Ethylpyrrolidin-2-yl]methyl}(5-nitro-1-benzofuran-7-yl)amineYield 100%

Procedure

The title compound was prepared according to the procedure described for Intermediate 27 using (R)-2-aminomethyl-1-ethylpyrrolidine. Yield: 100%, HPLC purity=90%, m/z=290 (M+H)+.

Sources & evidence

ORD record
ord-f564c1ba413f4563bf0593b460b026f0
Source dataset
uspto-grants-2010_10
Patent number
US07820675B2

Reaction notes

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