HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrazine → 7-[3-(Trifluoromethyl)piperazin-1-yl]-1-benzofuran-5-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrazine | HCID 9321 | — |
| Reactant | 1-(5-Nitro-1-benzofuran-7-yl)-3-(trifluoromethyl)piperazine | HCID 66892016 | — |
| Catalyst | Nickel | HCID 935 | — |
| Solvent | Ethanol | HCID 702 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 7-[3-(Trifluoromethyl)piperazin-1-yl]-1-benzofuran-5-amine | HCID 66893365 | 63% |
Reaction Steps
1-(5-Nitro-1-benzofuran-7-yl)-3-(trifluoromethyl)piperazine (96.6 mg, 0.31 mmol; Intermediate 46) was dissolved in THF (6 mL) and EtOH (25 mL). Raney nickel (slurry in ethanol; 1 mL) and H2NNH2 (61.4 mg, 1.23 mmol) were added and the mixture was stirred at room temperature overnight. Filtration through Celite and concentration gave 7-[3-(trifluoromethyl)piperazin-1-yl]-1-benzofuran-5-amine (55 mg, 63%). This material was used in the next reaction step without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07820675B2 |
| Source dataset | uspto-grants-2010_10 |
| ORD ID | ord-5e7ecdad6b55464297c350a36bb1f5b5 |
| Source note | uspto-grants-2010_10 |