Pyridine → HCID 66893944, compound

Participants

Reaction Steps

Benzenesulfonyl chloride (64.0 mg, 0.36 mmol) and pyridine (219 μL) were added to tert-butyl[1-(5-amino-1-benzofuran-7-yl)piperidin-4-yl]carbamate (100.0 mg, 0.30 mmol; Intermediate 49) in DCM (1 mL). The mixture was shaken at room temperature for 1 h, solvent was removed in vacuo and the residue was purified by preparative HPLC using acetonitrile-water gradients containing 0.1% trifluoroacetic acid. N-deprotection and conversion into the hydrochloride salt was performed by treatment with 2 M HCl in ether. This furnished 31.3 mg (28%) of the title product. HPLC 100%, RT: 1.612 (System A; 10-97% MeCN over 3 min). 1H NMR (500 MHz, DMSO-d6) δ ppm 1.69-1.70 (m, 2H) 2.00-2.01 (m, 2H) 2.76 (t, J=11.30 Hz, 2H) 3.18-3.26 (m, 1H) 6.54 (d, J=1.88 Hz, 1H) 6.82 (d, J=2.20 Hz, 1H) 6.86 (d, J=1.88 Hz, 1H) 7.52 (t, J=7.54 Hz, 2H) 7.57-7.68 (m, 1H) 7.71-7.72 (m, 2H) 7.88 (d, J=2.20 Hz, 1H) 8.14 (s, 3H) 10.03 (s, 1H). LC-MS 372 (M+H)+.

Provenance & Evidence