Hydrazine hydrate (1:1) → HCID 66893657, compound

Participants

Reaction Steps

To a solution of tert-butyl cis-3-fluoro-4-[(5-nitro-1-benzofuran-7-yl)oxy]piperidine-1-carboxylate (200 mg, 0.526 mmol; Intermediate 50) dissolved in THF (10 mL) and ethanol (40 mL), was added Raney-nickel (as a slurry in ethanol) and hydrazine hydrate (0.2 mL). The mixture was stirred at room temperature for 30 min and then filtered through Celite and evaporated. The residue was re-dissolved in toluene and evaporated again. This material was used directly in the subsequent experiment.

Provenance & Evidence