2-Trifluoromethylbenzenesulphonyl chloride → HCID 66891176, compound

Participants

Reaction Steps

The title compound was prepared according to the procedure described for Example 84 starting from tert-butyl trans-4-[(5-amino-1-benzofuran-7-yl)oxy]-3-fluoropiperidine-1-carboxylate (Intermediate 53) and 2-(trifluoromethyl)benzenesulfonyl chloride. Yield: 49 mg (25%), HPLC purity=100%, m/z=459 (M+H)+, 1H NMR (270 MHz, methanol-d4) δ ppm 2.13-2.31 (m, 2H) 3.15-3.56 (m, 3H) 3.64-3.79 (m, 1H) 4.77-4.97 (m, 1H) 5.00-5.24 (m, 1H) 6.75 (d, J=1.98 Hz, 1H) 6.81-6.84 (m, 1H) 6.99 (d, J=1.73 Hz, 1H) 7.60-7.77 (m, 3H) 7.87-7.95 (m, 1H) 7.98-8.05 (m, 1H).

Provenance & Evidence