2-Chlorobenzenesulfonyl chloride → HCID 66892942, compound

Participants

Reaction Steps

The title compound was prepared according to the procedure described for Example 84 starting from tert-butyl trans-4-[(5-amino-1-benzofuran-7-yl)oxy]-3-fluoropiperidine-1-carboxylate (Intermediate 53) and 2-chlorobenzenesulfonyl chloride. Yield: 40 mg (22%), HPLC purity=100%, m/z=425 (M+H)+, 1H NMR (270 MHz, methanol-d4) δ ppm 2.09-2.35 (m, 2H) 3.10-3.57 (m, 3H) 3.62-3.79 (m, 1H) 4.73-4.96 (m, 1H) 4.97-5.23 (m, 1H) 6.74 (d, J=2.23 Hz, 1H) 6.85 (d, J=1.98 Hz, 1H) 7.05 (d, J=1.73 Hz, 1H) 7.31-7.40 (m, 1H) 7.45-7.58 (m, 2H) 7.71 (d, J=2.23 Hz, 1H) 7.96 (dd, J=7.79, 1.61 Hz, 1H).

Provenance & Evidence