3-Methylbenzenesulphonyl chloride → HCID 66892952, compound

Participants

Reaction Steps

The title compound was prepared according to the procedure described for Example 84 starting from tert-butyl trans-4-[(5-amino-1-benzofuran-7-yl)oxy]-3-fluoropiperidine-1-carboxylate (Intermediate 53) and 3-methylbenzenesulfonyl chloride. Yield: 47 mg (27%), HPLC purity=100%, m/z=405 (M+H)+, 1H NMR (270 MHz, methanol-d4) δ ppm 2.12-2.34 (m, 2H) 2.28-2.34 (m, 3H) 3.15-3.57 (m, 3H) 3.64-3.78 (m, 1H) 4.73-4.97 (m, 1H) 4.98-5.21 (m, 1H) 6.71-6.79 (m, 2H) 7.25-7.57 (m, 4H) 7.70-7.74 (m, 1H).

Provenance & Evidence