2-Chlorobenzenesulfonyl chloride → HCID 66891802, compound

Participants

Reaction Steps

The title compound was prepared according to the procedure of Example 106, Step 3, starting from 4-(5-amino-benzofuran-7-ylmethyl)-1,4-diazepane-1-carboxylic acid tert-butyl ester (36 mg, 0.10 mmol; obtained in Step 2) and 2-chlorobenzenesulfonyl chloride (21 μL, 0.16 mmol). The crude material was purified with preparative HPLC (System B; 10-40% MeCN). The title compound (16 mg, 33%) was obtained as a colorless solid. HPLC 95%, RT=1.31 min (System A; 10-97% MeCN over 3 min), 96%, RT=1.17 min (System B; 10-97% MeCN over 3 min). 1H NMR (400 MHz, methanol-d4) δ ppm 2.25-2.37 (m, 2H) 3.41-3.48 (m, 2H) 3.48-3.59 (m, J=4.52 Hz, 2H) 3.69-3.75 (m, J=3.51 Hz, 2H) 3.74-3.83 (m, 2H) 4.70 (s, 2H) 6.86 (d, J=2.26 Hz, 1H) 7.36-7.41 (m, 1H) 7.42 (d, J=2.01 Hz, 1H) 7.51-7.59 (m, 3H) 7.85 (d, J=2.01 Hz, 1H) 8.00-8.04 (m, J=7.91, 1.13 Hz, 1H). MS (ESI+) for C20H22ClN3O3S m/z 420 (M+H)+.

Provenance & Evidence