反应详情

tert-Butyl trans-4-[(5-amino-1-benzofuran-7-yl)methyl]-2,5-dimethylpiperazine-1-carboxylate (0.037 g, 0.1 mmol; obtained in Step 3) was dissolved in DCM and reacted with 2-methoxy-5-methylbenzenesulfonyl chloride (0.045 g, 0.2 mmol) and pyridine (0.024 g, 0.3 mmol) overnight. The mixture was washed with 1 M HCl and the organic layer was dried (MgSO4) and evaporated. The crude was purified using flashtube (10% MeOH in DCM) and afforded the title product (0.026 g, 48%). HPLC 93% RT=2.01 min (System A; 10-97% MeCN over 3 min), 93% RT=1.85 min (System B; 10-97% MeCN over 3 min). MS (ESI+) m/z 544.2 (M+H)+.

1. washThe mixture was washed with 1 M HCl
2. dry with materialthe organic layer was dried (MgSO4)
3. customevaporated
4. customThe crude was purified