Methyl 2,3-dihydrobenzofuran-7-carboxylate → HCID 66893378, compound

Participants

Reaction Steps

To methyl 2,3-dihydro-1-benzofuran-7-carboxylate (1 g, 5.6 mmol; Intermediate 65) were 2-methoxy-5-methylbenzenesulfonic acid (1.13 g, 5.6 mmol) and phosphorus pentoxide-methanesulfonic acid solution (1:10; 13.5 mL) added. The mixture was stirred at room temperature for 48 h. Additional 2-methoxy-5-methylbenzenesulfonic acid (0.56 g, 2.8 mmol) was added and the reaction mixture was stirred at 50° C. for 15 h. The mixture was poured onto water/ice and the formed precipitate was filtrated off, dissolved in DCM and evaporated. The crude product was purified using flash chromatography (eluent: isohexane:EtOAc 1:1) yielding the title compound. Yield: 1.07 g (53%). MS (ESI+) for C18H18O6S m/z 363 (M+H)+.

Provenance & Evidence