Benzoyl Peroxide → HCID 66893431, compound

Participants

Reaction Conditions

Reaction Steps

Methyl 5-[(2-methoxy-5-methylphenyl)sulfonyl]-2,3-dihydro-1-benzofuran-7-carboxylate (879 mg, 2.4 mmol; Intermediate 66) was dissolved in chlorobenzene (6 mL). N-bromosuccinimide (432 mg, 2.4 mmol) and benzoyl peroxide (58 mg, 0.24 mmol) were added and the mixture was stirred at 100° C. for 17 h. The mixture was washed with saturated aqueous NaHCO3 and the organic layer was concentrated. Yield: 405 mg (46%) after purification by preparative HPLC (System F; 40-60% MeCN). MS (ESI+) for C18H16O6S m/z 361 (M+H)+.

Provenance & Evidence