Water → HCID 66894542, compound

Participants

Reaction Steps

Methyl 5-[(2-methoxy-5-methylphenyl)sulfonyl]-1-benzofuran-7-carboxylate (400 mg, 1.1 mmol; Intermediate 67) was dissolved in dry THF (3 mL) and 1 M lithium aluminiumhydride in THF (0.3 mL) was slowly added. The mixture was stirred at room temperature overnight. After this time, water (0.15 mL) was added and stirring was continued for 10 min, followed by the addition of 2 M aqueous NaOH (0.15 mL) and water (0.45 mL). The precipitate formed was filtered off and the solvent was evaporated. The crude product was used in the next step without further purification. MS (ESI+) for C17H16O5S m/z 333 (M+H)+.

Provenance & Evidence