2-Pyridinemethanamine → HCID 57470619, compound

HRID 1162091Notes

Reaction equation

HRID 1162091 reaction equation
[Br:1][C:2]1[N:6]2[N:7]=[C:8](Cl)[CH:9]=[CH:10][C:5]2=[N:4][CH:3]=1.[NH2:12][CH2:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][N:15]=1.C(Cl)Cl.CO.[NH4+].[OH-]>>[Br:1][C:2]1[N:6]2[N:7]=[C:8]([NH:12][CH2:13][C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][N:15]=3)[CH:9]=[CH:10][C:5]2=[N:4][CH:3]=1

Participants

4

Reactant 3

HCID 195092-PyridinemethanamineHCID 128723233-Bromo-6-chloroimidazo(1,2-b)pyridazineHCID 21896990Dichloromethane methanol ammonium hydroxide

Product 1

HCID 57470619HCID 57470619, compound

Procedure

Prepared from 3-bromo-6-chloroimidazo[1,2-b]pyridazine and 2-(aminomethyl)pyridine according to general procedure 1 providing the amino compound (97 mg, 25%) as a white solid; Rf=0.80 (CH2Cl2/MeOH/NH4OH, 160:18:2); 1H NMR (500 MHz, CD3OD) δ 8.52-8.51 (m, 1H), 7.83-7.79 (m, 1H), 7.63 (d, J=9.7 Hz, 1H), 7.59 (d, J=7.9 Hz, 1H), 7.41 (s, 1H), 7.33-7.31 (m, 1H), 6.84 (d, J=9.7 Hz, 1H), 4.70 (s, 2H); ES-MS: (M+H)=304, 306 m/z.

Sources & evidence

ORD record
ord-6683b0f47f9841179a3827f1d035280d
Source dataset
uspto-grants-2010_10
Patent number
US07820670B2

Reaction notes

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