Hydrochloric Acid → HCID 68648012, compound

Participants

Reaction Steps

Prepared from 6-chloroimidazo[1,2-b]pyridazine (4) and 2-(aminomethyl)pyridine according to general procedure 2. The free-base was converted to the HCl salt with 2N HCl in Et2O to provide the title compound (135 mg, 40%) as a white solid; 1H NMR (500 MHz, CD3OD) δ 8.68-8.67 (m, 1H), 8.27 (dt, J=1.5, 9.4 Hz, 1H), 8.03 (d, J=10 Hz, 1H), 7.99-7.98 (m, 1H), 7.90-7.87 (m, 2H), 7.72 (t, J=6.5 Hz, 1H), 7.40 (d, J=10 Hz, 1H), 4.80 (s, J=Hz, 2H); 13C NMR (75 MHz, CD3OD) δ 157.2, 156.8, 145.7, 144.4, 134.0, 125.9, 125.7, 122.3, 121.9, 121.4, 119.7, 45.5; HPLC tR=6.3 min (Luna), 98.9%; ES-MS: (M+H)=226 m/z.

Provenance & Evidence