Hydrochloric Acid → HCID 68648180, compound

Participants

Reaction Steps

Prepared from 6-chloro-3-(methoxymethyl)imidazo[1,2-b]pyridazine (8a) and 2-(aminomethyl)pyridine according to general procedure 4 (step B). The free-base was converted to the HCl salt with 2N HCl in Et2O to provide the title compound (13 mg, 12%) as a white solid; 1H NMR (500 MHz, CD3OD) δ 8.56 (d, J=5.1 Hz, 1H), 7.95 (m, 2H), 7.84 (s, 1H), 7.63 (d, J=7.9 Hz, 1H), 7.43 (dd, J=5.8, 7.8 Hz, 1H), 7.31 (d, J=9.9 Hz, 1H), 4.75 (s, 2H), 4.64 (s, 2H), 3.30 (s, 3H); 13C NMR (75 MHz, CD3OD) δ 158.4, 156.7, 148.7, 140.4, 134.5, 128.5, 124.5, 124.1, 122.4, 122.1, 120.5, 62.7, 58.8, 47.1; HPLC tR=4.2 min (Luna), 95.7%; ES-MS: (M+H)=270 m/z.

Provenance & Evidence