Hydrochloric Acid → HCID 57470626, compound

Participants

Reaction Steps

Prepared from 6-chloroimidazo[1,2-b]pyridazine (4) and 3-morpholinopropylamine according to general procedure 2. The free-base was converted to the HCl salt with 2N HCl in Et2O to provide the title compound (125 mg, 32%) as a brown solid; 1H NMR (500 MHz, CD3OD) δ 7.73 (s, 1H), 7.63 (d, J=9.8 Hz, 1H), 7.45 (d, J=1.2 Hz, 1H), 6.74 (d, J=9.8 Hz, 1H), 3.89-3.88 (m, 4H), 3.45 (t, J=6.6 Hz, 2H), 3.20-3.13 (m, 6H), 2.14-2.08 (m, 2H); 13C NMR (125 MHz, CD3OD) δ 155.7, 137.0, 129.6, 125.2, 118.0, 115.8, 65.6, 56.9, 53.5, 39.7, 24.6; HPLC tR=6.5 min (Luna), >99%; ES-MS: (M+H)=262 m/z.

Provenance & Evidence