1-Pyrrolidinepropanamine → HCID 58857922, compound

HRID 1162141Notes

Reaction equation

HRID 1162141 reaction equation
[Br:1][C:2]1[N:6]2[N:7]=[C:8](Cl)[CH:9]=[CH:10][C:5]2=[N:4][CH:3]=1.[N:12]1([CH2:17][CH2:18][CH2:19][NH2:20])[CH2:16][CH2:15][CH2:14][CH2:13]1>>[Br:1][C:2]1[N:6]2[N:7]=[C:8]([NH:20][CH2:19][CH2:18][CH2:17][N:12]3[CH2:16][CH2:15][CH2:14][CH2:13]3)[CH:9]=[CH:10][C:5]2=[N:4][CH:3]=1

Participants

3

Reactant 2

HCID 316701-PyrrolidinepropanamineHCID 128723233-Bromo-6-chloroimidazo(1,2-b)pyridazine

Product 1

HCID 58857922HCID 58857922, compound

Procedure

Prepared from 3-bromo-6-chloroimidazo[1,2-b]pyridazine and 3-(pyrrolidin-1-yl)propan-1-amine according to general procedure 1 providing the intermediate (227 mg, 81%) as a clear oil; 1H NMR (500 MHz, CDCl3) δ 7.53 (d, J=9.6 Hz, 1H), 7.44 (s, 1H), 6.40 (brs, 1H), 6.35 (d, J=9.6 Hz, 1H), 3.52 (quart, J=5.2 Hz, 2H), 2.67 (t, J=6.2 Hz, 2H), 2.57-2.54 (m, 4H), 1.86 (quin, J=6.3 Hz, 2H), 1.84-1.78 (m, 4H); ES-MS: (M+H)=324, 326 m/z.

Sources & evidence

ORD record
ord-ed5c6fda0ad845db91a3de8d3549947d
Source dataset
uspto-grants-2010_10
Patent number
US07820670B2

Reaction notes

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