Acetic Acid → HCID 68647810, compound

Participants

Reaction Conditions

Reaction Steps

Add 3,4-dimethoxy benzaldehyde 26 g (0.16 mol), ethyl cyanoacetate 18 g (0.16 mol), piperidine 0.8 ml, acetic acid 2.4 g, and benzene 60 ml into 250 ml eggplant-shaped flask, increase temperature to 120-130° C. for intensive reflux, separate water with water separator, react for 12 h. Vacuum evaporate to remove benzene, pour ice water into the reaction solution to precipitate yellow solid, filter and dry to obtain pale yellow crystal VIII-b-2 41 g, with yield almost reaching theoretical value and m.p. 154-156° C. (reference value 156° C.).

Provenance & Evidence