Acetic Acid → HCID 178434811, compound

Participants

Reaction Steps

2-(6-Fluoro-1H-indol-3-yl)-5,5-dimethylcyclohexane-1,3-dione of Example 3a (0.575 g, 2.1 mmol) was slowly added at room temperature under stirring to a freshly prepared mixture of acetic acid (2 mL), acetic anhydride (2.1 mL) and 70% aqueous perchloric acid (0.17 mL). The reaction mixture was stirred at room temperature for 4 h, diethyl ether (5 mL) was added, and the product was filtered off, washed with diethyl ether and dried at room temperature to give 0.72 g (89%) of the bright yellow crystals. The product was used in the next step without purification.

Provenance & Evidence