Anthranilic Acid → HCID 24771128, compound

HRID 1162174Notes

Reaction equation

HRID 1162174 reaction equation
F[C:2]1[CH:10]=[C:9]2[C:5]([C:6]([CH:11]3[C:16](=O)[CH2:15][C:14]([CH3:19])([CH3:18])[CH2:13][C:12]3=[O:20])=[CH:7][NH:8]2)=[CH:4][CH:3]=1.NC1C=C([Cl:31])C=CC=1C(O)=O.C(O)(=O)[C:33]1[C:34](=CC=CC=1)[NH2:35]>>[Cl:31][C:2]1[CH:3]=[CH:4][C:5]2[C:6]3[C:11]4[C:12](=[O:20])[CH2:13][C:14]([CH3:19])([CH3:18])[CH2:15][C:16]=4[N:35]=[C:34]([CH3:33])[C:7]=3[NH:8][C:9]=2[CH:10]=1

Participants

4

Reactant 3

HCID 227Anthranilic AcidHCID 666462-Amino-4-chlorobenzoic acidHCID 59520033HCID 59520033, compound

Product 1

HCID 24771128HCID 24771128, compound

Procedure

Utilizing the procedures described in Example 3 a-c except substituting 2-(6-chloro-1H-indol-3-yl)-5,5-dimethylcyclohexane-1,3-dione for 2-(6-fluoro-1H-indol-3-yl)-5,5-dimethylcyclohexane-1,3-dione in step 3a, and 2-amino-4-chlorobenzoic acid for anthranilic acid in step 1a of Example 1, the title compound was prepared and crystallized from toluene; m.p. 248-250° C.

Workup

  1. customcrystallized from toluene

Sources & evidence

ORD record
ord-e12b1d2cceff43dc815e54accedecc16
Source dataset
uspto-grants-2010_10
Patent number
US07820691B2

Reaction notes

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