Anthranilic Acid → HCID 24771189, compound

HRID 1162178Notes

Reaction equation

HRID 1162178 reaction equation
[F:1][C:2]1[CH:10]=[C:9]2[C:5]([C:6]([CH:11]3[C:16](=[O:17])[CH2:15][C:14]([CH3:19])([CH3:18])[CH2:13][C:12]3=O)=[CH:7][NH:8]2)=[CH:4][CH:3]=1.NC1C=C([F:31])C(F)=CC=1C(O)=O.C(O)(=O)[C:34]1[C:35](=CC=CC=1)[NH2:36]>>[F:1][C:2]1[C:3]([F:31])=[CH:4][C:5]2[C:6]3[C:11]4[C:16](=[O:17])[CH2:15][C:14]([CH3:18])([CH3:19])[CH2:13][C:12]=4[N:36]=[C:35]([CH3:34])[C:7]=3[NH:8][C:9]=2[CH:10]=1

Participants

4

Reactant 3

HCID 227Anthranilic AcidHCID 7359652-Amino-4,5-difluorobenzoic acidHCID 59520033HCID 59520033, compound

Product 1

HCID 24771189HCID 24771189, compound

Procedure

Utilizing the procedures described in Example 3 a-c except substituting 2-(5,6-difluoro-1H-indol-3-yl)-5,5-dimethyl-cyclohexane-1,3-dione for 2-(6-fluoro-1H-indol-3-yl)-5,5-dimethylcyclohexane-1,3-dione in step 3a, and 2-amino-4,5-difluorobenzoic acid for anthranilic acid in step 1a of Example 1, the title compound was prepared and crystallized from toluene; m.p. 260-252° C.

Workup

  1. customcrystallized from toluene

Sources & evidence

ORD record
ord-953eba921ac44bba882cfc87c3db9f1b
Source dataset
uspto-grants-2010_10
Patent number
US07820691B2

Reaction notes

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