Anthranilic Acid → HCID 24771190, compound

HRID 1162179Notes

Reaction equation

HRID 1162179 reaction equation
F[C:2]1[CH:10]=[C:9]2[C:5]([C:6]([CH:11]3[C:16](=[O:17])[CH2:15][C:14]([CH3:19])([CH3:18])[CH2:13][C:12]3=O)=[CH:7][NH:8]2)=[CH:4][CH:3]=1.NC1C=CC([F:31])=CC=1C(O)=O.C(O)(=O)[C:33]1[C:34](=CC=CC=1)[NH2:35]>>[F:31][C:3]1[CH:2]=[CH:10][C:9]2[NH:8][C:7]3[C:34]([CH3:33])=[N:35][C:12]4[CH2:13][C:14]([CH3:19])([CH3:18])[CH2:15][C:16](=[O:17])[C:11]=4[C:6]=3[C:5]=2[CH:4]=1

Participants

4

Reactant 3

HCID 227Anthranilic AcidHCID 1014122-Amino-5-fluorobenzoic acidHCID 59520033HCID 59520033, compound

Product 1

HCID 24771190HCID 24771190, compound

Procedure

Utilizing the procedures described in Example 3 a-c except substituting 2-(5-fluoro-1H-indol-3-yl)-5,5-dimethylcyclohexane-1,3-dione for 2-(6-fluoro-1H-indol-3-yl)-5,5-dimethylcyclohexane-1,3-dione in step 3a, and 2-amino-5-fluorobenzoic acid for anthranilic acid in step 1a of Example 1, the title compound was prepared and crystallized from toluene; m.p. 229-230° C.

Workup

  1. customcrystallized from toluene

Sources & evidence

ORD record
ord-75de9cc4b6da48589fdf5e7e5ced7224
Source dataset
uspto-grants-2010_10
Patent number
US07820691B2

Reaction notes

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