Ethylamine → HCID 16117213, compound

Participants

Reaction Steps

Using the same procedure as in Example 5, methyl [(4-{[1-(pyridin-2-ylmethyl)-1H-indazol-5-yl]amino}quinazolin-5-yl)oxy]acetate (250 mg, 0.55 mmol) was reacted with ethylamine to give the title compound as a beige solid (140 mg, 56%); NMR Spectrum 1.09 (t, 3H), 3.23 (m, 2H), 4.87 (s, 2H), 5.77 (s, 2H), 6.97 (m, 2H), 7.29 (m, 1H), 7.37 (d, 1H), 7.76-7.69 (m, 3H), 7.83 (m, 1H), 8.16 (s, 1H), 8.38 (br t, 1H), 8.56-8.53 (m, 3H), 10.85 (br s, 1H); Mass spectrum MH+ 454.

Provenance & Evidence