Ethanolamine → HCID 16117214, compound

Participants

Reaction Steps

Using the same procedure as in Example 5, methyl [(4-{[1-(pyridin-2-ylmethyl)-1H-indazol-5-yl]amino}quinazolin-5-yl)oxy]acetate (250 mg, 0.55 mmol) was reacted with ethanolamine (0.333 ml, 5.5 mmol) to give the title compound as a white solid (220 mg, 85%), except that the reaction was run at 45° C. for 2 days. NMR Spectrum 3.30 (m, 2H), 3.49 (m, 2H), 4.79 (m, 1H), 4.89 (s, 2H), 5.77 (s, 2H), 6.96 (m, 2H), 7.29 (m, 1H), 7.37 (d, 1H), 7.77-7.69 (m, 3H), 7.84 (m, 1H), 8.16 (s, 1H), 8.42 (br t, 1H), 8.57-8.53 (m, 3H), 10.87 (br s, 1H); Mass spectrum MH+ 470.

Provenance & Evidence