2-(Methylamino)ethanol → HCID 16117216, compound

Participants

Reaction Steps

Using the same procedure as in Example 5, methyl [(4-{[1-(pyridin-2-ylmethyl)-1H-indazol-5-yl]amino}quinazolin-5-yl)oxy]acetate (200 mg, 0.45 mmol) was reacted with 2-(methylamino)ethanol (0.219 ml, 2.73 mmol) to give the title compound as a white solid (130 mg, 59%), except that the reaction was run at 45° C. for 18 hours. NMR Spectrum (2 rotamers, ratio 2/1) 2.97 and 3.08 (s, 3H), 3.62-3.43 (m, 4H), 4.73 and 4.99 (t, 1H), 5.16 and 5.23 (s, 2H), 5.77 (s, 2H), 6.96 (d, 1H), 7.37-7.18 (m, 3H), 7.75-7.69 (m, 3H), 7.90 (m, 1H), 8.15 (s, 1H), 8.53 (m, 2H), 8.57 (s, 1H), 11.20 and 11.21 (br s, 1H); Mass spectrum MH+ 484.

Provenance & Evidence