Pyrrolidine → HCID 16117217, compound

Participants

Reaction Steps

Using the same procedure as in Example 5, methyl [(4-{[1-(pyridin-2-ylmethyl)-1H-indazol-5-yl]amino}quinazolin-5-yl)oxy]acetate (180 mg, 0.41 mmol) was reacted with pyrrolidine (0.205 ml, 2.45 mmol) to give the title compound as a light brown solid (160 mg, 82%), except that the reaction was run at 45° C. for 18 hours in the presence of 3 Å molecular sieve. NMR Spectrum 1.83 (m, 2H), 1.95 (m, 2H), 3.45 (t, 2H), 3.50 (t, 2H), 5.09 (s, 2H), 5.77 (s, 2H), 6.96 (d, 1H), 7.18 (d, 1H), 7.29 (m, 1H), 7.37 (d, 1H), 7.77-7.69 (m, 3H), 7.91 (m, 1H), 8.15 (s, 1H), 8.53 (s, 2H), 8.57 (s, 1H), 11.16 (br s, 1H); Mass spectrum MH+ 480.

Provenance & Evidence