Morpholine → HCID 16117218, compound

Participants

Reaction Steps

Using the same procedure as in Example 5, methyl [(4-{[1-(pyridin-2-ylmethyl)-1H-indazol-5-yl]amino}quinazolin-5-yl)oxy]acetate (180 mg, 0.40 mmol) was reacted with morpholine (0.346 ml, 3.96 mmol) to give the title compound as a solid (115 mg, 59%), except that the reaction was run at 60° C. for 32 hours in the presence of 3 Å molecular sieve. NMR Spectrum 3.68-3.52 (m, 8H), 5.20 (s, 2H), 5.77 (s, 2H), 6.96 (d, 1H), 7.23 (d, 1H), 7.30 (m, 1H), 7.37 (d, 1H), 7.77-7.68 (m, 3H), 7.90 (m, 1H), 8.15 (s, 1H), 8.53 (s, 2H), 8.56 (s, 1H), 11.18 (br s, 1H); Mass spectrum MH+ 496.

Provenance & Evidence