HuagongsheHuagongshe Chemistry Print Report · For research reference only
methyl (S)-lactate → methyl (2R)-2-[(4-{[1-(3-fluorobenzyl)-1H-indazol-5-yl]amino}quinazolin-5-yl)oxy]propanoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | methyl (S)-lactate | HCID 94386 | — |
| Reactant | 4-{[1-(3-fluorobenzyl)-1H-indazol-5-yl]amino}quinazolin-5-ol | HCID 136346721 | — |
| Product | methyl (2R)-2-[(4-{[1-(3-fluorobenzyl)-1H-indazol-5-yl]amino}quinazolin-5-yl)oxy]propanoate | HCID 86627837 | 69% |
Reaction Steps
4-{[1-(3-fluorobenzyl)-1H-indazol-5-yl]amino}quinazolin-5-ol was reacted with (S)-methyl lactate as described in Example 5, starting material to give methyl (2R)-2-[(4-{[1-(3-fluorobenzyl)-1H-indazol-5-yl]amino}quinazolin-5-yl)oxy]propanoate (760 mg, 69%); Mass spectrum 472.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07820683B2 |
| Source dataset | uspto-grants-2010_10 |
| ORD ID | ord-52a716b689cd4a1babbcfa6adc8496dd |
| Source note | uspto-grants-2010_10 |