Dimethylamine → HCID 16117623, compound

Participants

Reaction Steps

Using the same procedure as in Example 26, methyl (2S)-2-[(4-{[1-(1,3-thiazol-2-ylmethyl)-1H-indazol-5-yl]amino}quinazolin-5-yl)oxy]propanoate (250 mg, 0.54 mmol) was reacted with dimethylamine to give the title compound as a white solid (195 mg, 76%); NMR Spectrum 1.59 (d, 3H), 2.93 (s, 3H), 3.14 (s, 3H), 5.85 (q, 1H), 6.04 (s, 2H), 7.30 (d, 1H), 7.35 (d, 1H), 7.65 (d, 1H), 7.74 (m, 3H), 7.87 (dd, 1H), 8.20 (s, 1H), 8.51 (s, 1H), 8.55 (s, 1H), 11.15 (br s, 1H); Mass spectrum 474.

Provenance & Evidence