Ethanolamine → HCID 16117889, compound

Participants

Reaction Steps

Using the same procedure as in Example 26, methyl (2R)-2-[(4-{[1-(1,3-thiazol-4-ylmethyl)-1H-indazol-5-yl]amino}quinazolin-5-yl)oxy]propanoate (200 mg, 0.43 mmol) was reacted with ethanolamine (0.26 ml, 4.3 mmol) to give the title compound as a solid (170 mg, 80%), except that the mixture was heated at 45° C. for 20 hours. NMR Spectrum 1.65 (d, 3H), 3.22 (m, 2H), 3.43 (m, 2H), 4.75 (t, 1H), 5.23 (q, 1H), 5.79 (s, 2H), 7.02 (d, 1H), 7.36 (d, 1H), 7.51 (s, 1H), 7.79-7.72 (m, 3H), 8.11 (s, 1H), 8.48 (m, 1H), 8.51 (s, 2H), 9.04 (s, 1H), 10.72 (br s, 1H); Mass spectrum MH+ 490.

Provenance & Evidence