Sodium Hydroxide → HCID 68620045, compound

Participants

Reaction Steps

Aqueous sodium hydroxide (2N, 1 ml, 2 mmol) was added to a solution of methyl (2R)-2-[(4-{[1-(1,3-thiazol-4-ylmethyl)-1H-indazol-5-yl]amino}quinazolin-5-yl)oxy]propanoate (480 mg, 1 mmol) in THF (3 ml) and methanol (3 ml). The mixture was stirred at room temperature for 2 hours. After evaporation of the solvents, the pH of the mixture was adjusted to 3 by addition of 2N hydrochloric acid. The precipitate formed was filtered, washed with water and dried under high vacuum to give (2R)-2-[(4-{[1-(1,3-thiazol-4-ylmethyl)-1H-indazol-5-yl]amino}quinazolin-5-yl)oxy]propanoic acid (435 mg, 97%); Mass spectrum MH+ 447.

Provenance & Evidence