Dimethylamine → HCID 16117891, compound

Participants

Reaction Steps

Using the same procedure as in Example 5, methyl (2S)-2-[(4-{[1-(1,3-thiazol-4-ylmethyl)-1H-indazol-5-yl]amino}quinazolin-5-yl)oxy]propanoate (200 mg, 0.43 mmol) was reacted with dimethylamine to give the title compound as a solid (120 mg, 58%); NMR Spectrum 1.59 (d, 3H), 2.93 (s, 3H), 3.14 (s, 3H), 5.79 (s, 2H), 5.85 (q, 1H), 7.29 (d, 1H), 7.34 (d, 1H), 7.51 (s, 1H), 7.77-7.72 (m, 2H), 7.83 (m, 1H), 8.11 (s, 1H), 8.52 (m, 2H), 9.04 (s, 1H), 11.12 (br s, 1H); Mass spectrum MH+ 474.

Provenance & Evidence