Morpholine → HCID 16118034, compound

Participants

Reaction Steps

Using the same procedure as in Example 44, (2S)-2-[(4-{[1-(pyridin-2-ylmethyl)-1H-indazol-5-yl]amino}quinazolin-5-yl)oxy]propanoic acid (300 mg, 0.68 mmol) was reacted with morpholine to give the title compound as a white solid (120 mg, 34%); NMR spectrum 1.58 (d, 3H), 3.67-3.58 (m, 8H), 5.77 (s, 2H), 5.88 (q, 1H), 6.95 (d, 1H), 7.29 (m, 2H), 7.35 (d, 1H), 7.75-7.67 (m, 3H), 7.83 (m, 1H), 8.15 (s, 1H), 8.52 (m, 3H), 11.12 (s, 1H); Mass spectrum MH+ 510.

Provenance & Evidence