Ethylamine → HCID 16118183, compound

Participants

Reaction Steps

Using the same procedure as in Example 5, methyl (2R)-2-[(4-{[1-(1,3-thiazol-2-ylmethyl)-1H-indazol-5-yl]amino}quinazolin-5-yl)oxy]propanoate (200 mg, 0.43 mmol) was reacted with ethylamine to give the title compound as a white solid (158 mg, 77%); NMR Spectrum 1.04 (t, 3H), 1.65 (d, 3H), 3.17 (m, 2H), 5.15 (q, 1H), 6.04 (s, 2H), 7.01 (d, 1H), 7.37 (d, 1H), 7.66 (s, 1H), 7.72-7.80 (m, 4H), 8.21 (s, 1H), 8.44 (m, 1H), 8.54 (s, 1H), 8.56 (s, 1H), 10.71 (br s, 1H); Mass spectrum MH+ 474.

Provenance & Evidence