Tetrahydrofuran → HCID 23138257, compound

Participants

Reaction Steps

A solution of ethyl 3-(N′-(4-chlorophenyl)ureido)-2-phenylpropanoate (1.5 g) obtained in Example 4a) and 1 N sodium hydroxide (10 ml) in ethanol (20 ml)-THF (20 ml) was mixed at room temperature for 15 hours, and then the reaction solution was concentrated under reduced pressure. The solution was acidified by adding 1 N hydrochloric acid to the concentrated solution, and then extracted with ethyl acetate. The extract was washed with saturated brine and dried over anhydrous sodium sulfate. The solvent was distilled off under reduced pressure to obtain the title compound as colorless powder (1.4 g, quantitative).

Provenance & Evidence