Triethylamine → HCID 178455182, compound

Participants

Reaction Steps

To a solution of (4-(((1-benzyl-4-piperidinyl)amino)methyl)-1H-imidazol-2-yl)methanol (0.28 g) obtained in Example 83f) and triethylamine (0.26 ml) in dichloromethane (5 ml) was added tert-butyl dimethylchlorosilane (0.17 g), and mixed at room temperature for 3 hours. The reaction solution was diluted with chloroform and water. The organic layer was collected by separation, washed with saturated brine and dried over anhydrous magnesium sulfate. The solvent was distilled off under reduced pressure, and the residue was purified with basic silica gel column (ethyl acetate:ethanol=10:1) to obtain the title compound as a pale yellow oil (0.20 g, 52%).

Provenance & Evidence