Acetic Acid → HCID 58857966, compound

Participants

Reaction Steps

N-((1R)-1-((4-(5-(((tert-butyldimethylsilyl)oxy)methyl)-3-oxo-1H-imidazo[1,5-c]imidazol-2(3H)-yl)-1-piperidinyl)carbonyl)-2,2-dimethylpropyl)-N′-(4-chlorophenyl)urea (0.31 g) obtained in Example 831) was dissolved in a solution (acetic acid:water:THF=4:1:1, 6 ml), and mixed at 60° C. for 4 hours. The solvent was distilled off under reduced pressure, and then to the residue were added ethyl acetate and a saturated aqueous sodium hydrogen carbonate solution. The organic layer was collected by separation, washed with saturated brine and dried over anhydrous magnesium sulfate, and then the solvent was distilled off under reduced pressure. The residue was purified with basic silica gel column (ethyl acetate to ethyl acetate:ethanol=10:1) to obtain the title compound as a colorless solid (0.21 g, 85%).

Provenance & Evidence