反应详情

To a solution of tert-butyl 4-(aminomethyl)-1-piperidinecarboxylate (K. Ito et al., Eur. J. Med. Chem., 34, 977 (1999); 3.7 g), 2-methylimidazole-4-carbaldehyde (1.9 g) and acetic acid (1 ml) in 1,2-dichloroethane (100 ml) was added sodium triacetoxyborohydride (5.6 g), and mixed at room temperature for 15 hours. pH of the aqueous layer was adjusted to about 12 by adding a 1 N aqueous sodium hydroxide solution to the reaction solution, and then extracted with chloroform. The extract was dried over anhydrous magnesium sulfate, and then the solvent was distilled off under reduced pressure. The resulting yellow oil was dissolved in dichloromethane (100 ml), DBU (2.6 ml) and N,N′-carbonyldiimidazole (2.8 g) were added thereto, and mixed at room temperature for 15 hours. The reaction mixture was diluted with water and chloroform and the organic layer was collected by separation, and then dried over anhydrous magnesium sulfate. The solvent was distilled off under reduced pressure, and the residue was purified with silica gel column (ethyl acetate:ethanol=5:1) to obtain the title compound as a yellow oil (3.5 g, 59%).

1. additionmixed at room temperature for 15 hours
2. extractionextracted with chloroform
3. dry with materialThe extract was dried over anhydrous magnesium sulfate
4. distillationthe solvent was distilled off under reduced pressure
5. dissolutionThe resulting yellow oil was dissolved in dichloromethane (100 ml)
6. additionDBU (2.6 ml) and N,N′-carbonyldiimidazole (2.8 g) were added
7. additionmixed at room temperature for 15 hours
8. additionThe reaction mixture was diluted with water and chloroform
9. customthe organic layer was collected by separation
10. dry with materialdried over anhydrous magnesium sulfate
11. distillationThe solvent was distilled off under reduced pressure
12. customthe residue was purified with silica gel column (ethyl acetate:ethanol=5:1)