反应详情

N-(tert-butoxycarbonyl-4-piperidinyl)amine (4.8 g), 2,5-dimethylimidazole-4-carbaldehyde (3.0 g) and acetic acid (1.7 ml) were dissolved in 1,2-dichloroethane (50 ml), under ice-cooling, sodium triacetoxyborohydride (7.7 g) was added thereto, and mixed at room temperature for 15 hours. The reaction solution was poured into an aqueous potassium carbonate solution, and extracted with chloroform. The extract was dried over anhydrous magnesium sulfate, the solvent was distilled off under reduced pressure, and then the residue was purified with silica gel column to obtain a pale yellow oily title compound (8.0 g, quantitative).

1. temperaturecooling
2. additionmixed at room temperature for 15 hours
3. extractionextracted with chloroform
4. dry with materialThe extract was dried over anhydrous magnesium sulfate
5. distillationthe solvent was distilled off under reduced pressure
6. customthe residue was purified with silica gel column