Hydrochloric Acid → HCID 58857996, compound

Participants

Reaction Steps

To tert-butyl(1R)-2,2-dimethyl-1-((4-(2-methyl-5-oxo-5H-imidazo[1,5-a]imidazol-6(7H)-yl)-1-piperidinyl)carbonyl)propylcarbamate (0.17 g) obtained in Example 89c) was added a 40% solution of hydrogen chloride in ethanol (10 ml), and mixed for 1 hour. The reaction solution was concentrated under reduced pressure. The residue and triethylamine (0.16 ml) were dissolved in acetonitrile (15 ml) and a solution of 4-chlorophenyl isocyanate (72 mg) in acetonitrile (15 ml) was added dropwise thereto. The reaction mixture was mixed for 15 hours, then the solvent was distilled off under reduced pressure, and the residue was purified with silica gel column (ethyl acetate to ethyl acetate/methanol=5/1). The product was recrystallized from diethyl ether to obtain the title compound as colorless powder (0.17 g, 53%).

Provenance & Evidence