反应详情

To a suspension of 1-benzylpiperazine (18 g) and sodium carbonate (8.3 g) in acetone (50 ml) was added chloroacetonitrile (12 g) under ice-cooling, and mixed at room temperature for 2 hours. The reaction solution was concentrated under reduced pressure, to the residue were added water and diethyl ether, and the organic layer was collected by separation. The organic layer was washed with water and dried over anhydrous sodium sulfate, and then concentrated under reduced pressure. The residue was purified with silica gel column (ethyl acetate) to obtain the title compound as pale yellow liquid (17 g, 80%).

1. temperaturecooling
2. additionmixed at room temperature for 2 hours
3. concentrationThe reaction solution was concentrated under reduced pressure, to the residue
4. additionwere added water and diethyl ether
5. customthe organic layer was collected by separation
6. washThe organic layer was washed with water
7. dry with materialdried over anhydrous sodium sulfate
8. concentrationconcentrated under reduced pressure
9. customThe residue was purified with silica gel column (ethyl acetate)