HCID 23138454, compound → 856418-53-6

HRID 1162351Notes

Reaction equation

HRID 1162351 reaction equation
C([N:8]1[CH2:13][CH2:12][CH:11]([N:14]2[CH2:19][CH2:18][N:17]([C:20]([O:22][C:23]([CH3:26])([CH3:25])[CH3:24])=[O:21])[CH2:16][C:15]2=[O:27])[CH2:10][CH2:9]1)C1C=CC=CC=1>C(O)C.[C].[Pd]>[O:27]=[C:15]1[N:14]([CH:11]2[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]2)[CH2:19][CH2:18][N:17]([C:20]([O:22][C:23]([CH3:26])([CH3:25])[CH3:24])=[O:21])[CH2:16]1

Participants

4

Reactant 1

HCID 23138454HCID 23138454, compound

Product 1

HCID 23138143856418-53-6Yield 89.4%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 702EthanolSolvent

Procedure

tert-Butyl 4-(1-benzyl-4-piperidinyl)-3-oxo-1-piperazinecarboxylate (PCT Japanese Translation Patent Publication No. 2002533451; 1.4 g) was dissolved in ethanol (30 ml), 10% palladium carbon (50% water content; 0.12 g) was added thereto, and mixed under hydrogen atmosphere at room temperature for 16 hours. The reaction mixture was filtered, and the filtrate was concentrated under reduced pressure to obtain the title compound as a green oil (0.95 g, quantitative).

Workup

  1. additionmixed under hydrogen atmosphere at room temperature for 16 hours
  2. filtrationThe reaction mixture was filtered
  3. concentrationthe filtrate was concentrated under reduced pressure

Sources & evidence

ORD record
ord-cfab5ad0872f4c50a41b345444031b1d
Source dataset
uspto-grants-2010_10
Patent number
US07820673B2

Reaction notes

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