反应详情

1-Benzyl-4-(2-methyl-4-pyridinyl)piperazine (10.3 g) obtained in Example 114a) and 10% palladium carbon (1.0 g) were added to methanol (200 ml), and mixed under hydrogen atmosphere at room temperature for 7 days. The catalyst was filtered off, and the filtrate was concentrated under reduced pressure. The residue was purified with basic silica gel column (ethyl acetate) and recrystallized from ethyl acetate-hexane to obtain the title compound as a colorless needle-like crystal (2.58 g, 38%).

1. additionmixed under hydrogen atmosphere at room temperature for 7 days
2. filtrationThe catalyst was filtered off
3. concentrationthe filtrate was concentrated under reduced pressure
4. customThe residue was purified with basic silica gel column (ethyl acetate)
5. customrecrystallized from ethyl acetate-hexane